GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THCA | cis | rs515910 | 1 | rs556292 | chr10:105961957 | C10orf79 | chr10:105889647-105992120:- | 0.25 | 8.04 | 6.92E-15 | Attention deficit hyperactivity disorder |
| THCA | cis | rs3771570 | 1 | rs55634485 | chr2:242268994 | ANO7 | chr2:242127924-242164791:+ | 0.36 | 4.13 | 4.26E-5 | Prostate cancer |
| THCA | cis | rs3771570 | 1 | rs55634485 | chr2:242268994 | SEPT2 | chr2:242254723-242293439:+ | -0.29 | -4.17 | 3.59E-5 | Prostate cancer |
| THCA | cis | rs12134133 | 1 | rs55638602 | chr1:207428942 | CD55 | chr1:207494817-207534309:+ | 0.19 | 7.47 | 3.96E-13 | Posterior cortical atrophy and Alzheimer's disease |
| THCA | cis | rs3771570 | 1 | rs55645375 | chr2:242269024 | ANO7 | chr2:242127924-242164791:+ | 0.36 | 4.13 | 4.26E-5 | Prostate cancer |
| THCA | cis | rs3771570 | 1 | rs55645375 | chr2:242269024 | SEPT2 | chr2:242254723-242293439:+ | -0.29 | -4.17 | 3.59E-5 | Prostate cancer |
| THCA | cis | rs4785204 | 1 | rs55647424 | chr16:50092495 | HEATR3 | chr16:50099881-50139373:+ | -0.4 | -6.21 | 1.16E-9 | Esophageal cancer (squamous cell) |
| THCA | cis | rs7951870 | 1 | rs55657382 | chr11:46634963 | PACSIN3 | chr11:47199085-47207958:- | 0.18 | 4.13 | 4.22E-5 | Schizophrenia |
| THCA | cis | rs55661361 | 1 | rs55661361 | chr11:124613957 | NRGN | chr11:124609829-124617102:+ | 0.27 | 7.73 | 6.44E-14 | Schizophrenia |
| THCA | cis | rs1027730 | 1 | rs55664904 | chr8:94081319 | C8orf83 | chr8:93895865-94029901:- | 0.26 | 4.14 | 4.03E-5 | Attention deficit hyperactivity disorder |
| THCA | cis | rs7223966 | 1 | rs55674647 | chr17:61794195 | FTSJ3 | chr17:61896795-61905031:- | 0.31 | 5.59 | 3.75E-8 | Body mass index |
| THCA | cis | rs7223966 | 1 | rs55674647 | chr17:61794195 | MAP3K3 | chr17:61699775-61773669:+ | 0.26 | 5.05 | 6.4E-7 | Body mass index |
| THCA | cis | rs73201462 | 1 | rs55675294 | chr3:128043050 | EEFSEC | chr3:127872313-128127488:+ | -0.19 | -3.44 | 0.000634 | Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio |
| THCA | cis | rs17095355 | 1 | rs55683820 | chr10:111665376 | DUSP5 | chr10:112257625-112271300:+ | -0.14 | -3.71 | 0.000232 | Biliary atresia |
| THCA | cis | rs73201462 | 1 | rs55684215 | chr3:127812792 | EEFSEC | chr3:127872313-128127488:+ | -0.25 | -4.42 | 1.23E-5 | Post bronchodilator FEV1;Post bronchodilator FEV1/FVC ratio |